NSH Lecture

NSH Lectures

The Biological Stain Commission sponsors the annual National Society for Histotechnology International Lectureship at the NSH meetings.

The 35th Annual Symposium/Convention of the NSH will take place October 2-7, 2009 in Birmingham, AL.

Biological Stain Commission International Lecture

Dr Manfred Dietel
Institute of Pathology, Charité, Humboldt University Berlin, Germany

Applications of new immunological and molecular techniques play an increasing role in the routine process of tissue-based diagnostic of infectious and neoplastic diseases as well as in translational cancer research. The major up-coming challenges are
·    to directly detect a great spectrum of microorganisms in surgical specimens,
·    to preceisly and reproducibly diagnose malignant tumors, even rare lesions, and to establishe internationally accepted diagnostic algorithms,
·    to define the individual prognosis of the actual patient as precise as possible,
·    to asses the probability of metastases, e.g. in case of clinical state M0 at time of tumor diagnosis and
·    to predict response/resistance of each individual tumor against conventional or targeted anticancer drugs.
Due to continuous technical developments in immunohistochemistry (IHC) and in-situ hybrization (ISH) assisted by different molecular and computational techniques the power of diagnostic histopathology increased dramatically during the last decade. Among others the most impressive new innovations are
·    multicolor IHC
·    fluorescence and bright-filed ISH
·    combined IHC-ISH for double and triple stainings
·    tissue-adapted PCR and
·    tissue-based mutation analyses.
These approaches all have to be performed under standard operating procedures in order to guarantee reliable results to the benefit of the patients. Combined application of the different technologies will further improve the importance of histological diagnoses and their predictive accuracy. All further efforts should be directed to improve the tissue-based diagnosis and predictive relevance of surgical pathology and to provide the clinicians with all those information needed for optimal treatment.

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